Genetics

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Retina March 2025

Addressing Multiplicity in Retinal Sensitivity Analysis: An Alternative Approach to Assessing Gene Therapy Efficacy in Inherited Retinal Diseases

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Antonio Yaghy; David G. Birch; Yunchan Hwang; Edmund Luo; JungAh Jung; Darin Curtiss; Nadia K. Waheed
TAGS: gene therapy, retinal diseases, sensitivity analysis, treatment effect
Trans. Vis. Sci. Tech.. 2025; 14(3):25. https://doi.org/10.1167/tvst.14.3.25

Retina March 2025

Topical Administration of Novel FKBP12 Ligand MP-004 Improves Retinal Function and Structure in Retinitis Pigmentosa Models

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Araceli Lara-López; Klaudia Gonzalez-Imaz; María Rodríguez-Hidalgo; Miren Sarasola-Gastesi; Leire Escudero-Arrarás; Santiago Milla-Navarro; Pedro de la Villa; Maialen Sagartzazu-Aizpurua; José Ignacio Miranda; Jesús María Aizpurua; Adolfo López de Munain; Ainara Vallejo-Illarramendi; Javier Ruiz-Ederra
TAGS: calcium, ligands, mice, photoreceptors, retinitis pigmentosa, tacrolimus binding protein 1a, administration, topical, retina, oxidative stress, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):56. https://doi.org/10.1167/iovs.66.3.56

Includes: Supplemental Content

Retina March 2025

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

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Rajya L. Gurung; Charvi Nangia; Tengda Cai; Liesel M. FitzGerald; Bennet J. McComish; Ebony Liu; Georgia Kaidonis; Bronwyn Ridge; Alex W. Hewitt; Brendan Vote; Nitin Verma; Jamie E. Craig; Colin N. A. Palmer; Kathryn P. Burdon; Weihua Meng
TAGS: cohort studies, diabetes mellitus, genetics, genome-wide association study, macular disorders, meta-analysis, single nucleotide polymorphism, genotype determination, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):55. https://doi.org/10.1167/iovs.66.3.55

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis

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Hua Zhang; Shuning Lan; Disuo Ren; Xiaoyan Chen; Yong Lin; Qiongjie Cao; Weiwei Xu; Jiao Wang; Peter Sol Reinach; Dongsheng Yan; Guangying Luo
TAGS: cornea, dna methylation, epigenetics, epithelium, genes, rna, tumorigenesis, wound healing, neoplasms, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):54. https://doi.org/10.1167/iovs.66.3.54

Includes: Supplemental Content

Cornea March 2025

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

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Shiding Li; Hao Sun; Fei Fang; Siyi Zhang; Junzhao Chen; Chunyi Shao; Yao Fu; Liangbo Chen
TAGS: body tissue, cell communication, cornea, epithelial stem cells, epithelium, fluorescent antibody technique, genes, rna, small cytoplasmic, transcriptomics, melanocytes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):52. https://doi.org/10.1167/iovs.66.3.52

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2025

Clinical Value of MLPA for Prognostic Assessment of Chromosomal Rearrangements and DNA Methylation in Uveal Melanoma

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Andrea Soltysova; Dana Dvorska; Andrej Ficek; Martina Pecimonova; Marek Samec; Ivana Kasubova; Viera Horvathova Kajabova; Lucia Demkova; Pavel Babal; Jela Valaskova; Zuzana Dankova; Bozena Smolkova; Alena Furdova
TAGS: chromosome rearrangements, dna methylation, methylation, patient prognosis, uveal melanoma, dna, neoplasms
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):51. https://doi.org/10.1167/iovs.66.3.51

Includes: Supplemental Content

Retina March 2025

Optic Nerve Crush Does Not Induce Retinal Ganglion Cell Loss in the Contralateral Eye

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Florianne E. Schoot Uiterkamp; Margaret E. Maes; Mohammad Amin Alamalhoda; Arsalan Firoozi; Gloria Colombo; Sandra Siegert
TAGS: eye, mice, microglia, optic nerve, retina, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):49. https://doi.org/10.1167/iovs.66.3.49

Includes: Supplemental Content

Glaucoma March 2025

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells

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Yong-Feng Yang; Paul Holden; Ying Ying Sun; Jennifer A. Faralli; Donna M. Peters; Kate E. Keller
TAGS: fibrosis, genes, glaucoma, proteins, trabecular meshwork
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):48. https://doi.org/10.1167/iovs.66.3.48

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

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Mingsu Shi; Rongmei Zhou; Weiai Shen; Yu Liang; Yihan Zhang; Lingyun Liu; Runyi Shao; Yanxi Fang; Chen Zhao; Lianqun Wu
TAGS: bodily secretions, genes, graves' ophthalmopathy, muscle of orbit, polymerase chain reaction, rna, sequence analysis, rna, sincalide, cell proliferation, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):46. https://doi.org/10.1167/iovs.66.3.46

Includes: Supplemental Content

Retinal Cell Biology March 2025

Pten Loss Triggers Progressive Photoreceptor Degeneration in an mTORC1-Independent Manner

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Joseph Hanna; Yacine Touahri; Alissa Pak; Luke Ajay David; Edwin van Oosten; Rajiv Dixit; Laura M. Vecchio; Dhruv Nimesh Mehta; Ren Minamisono; Isabelle Aubert; Carol Schuurmans
TAGS: mechanistic target of rapamycin complex 1, photoreceptors, pten gene, retina, tissue degeneration, rod photoreceptors, precipitating factors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):45. https://doi.org/10.1167/iovs.66.3.45

Includes: Supplemental Content

Low Vision March 2025

EFEMP1-Mediated Regulation of Choroidal Vascular Dysfunction in Myopia: Insights Into the FOXO3/VEGFA Pathway as a Therapeutic Target

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Wen-Qing Shi; Bing Li; Yuting Shao; Wenting Han; Yule Xu; Qing Jiang; Shen Qu; Xiaodong Zhou; Yanlong Bi
TAGS: forkhead box protein o3, myopia, pathophysiology, caviidae, regulation, choroid, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):43. https://doi.org/10.1167/iovs.66.3.43

Includes: Supplemental Content

Retinal Cell Biology March 2025

Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling

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Xiaodi Zhou; Xiaoxiao Xu; Qiong Wang; Yanting Lai; Linyan Zhang; Yunfeng Lin; Xiaoyan Ding; Limei Sun
TAGS: endothelial cells, hypoxia, notch1 gene, retinal neovascularization, rna, small interfering, signal transduction, proteins, neovascularization, pathologic, ischemia, fluorescence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):39. https://doi.org/10.1167/iovs.66.3.39

Clinical and Epidemiologic Research March 2025

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

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Yue Li; Jiaqi Tang; Gaojing Jing; Yueyue Li; Rui Ma; Xin Kang; Liyuan Rong; Wenlu Liu; Lan Yao; Xiaohui Lv; Aijun Deng; Wei Wu; Xinji Yang
TAGS: connective tissue, cytokine, histopathology tests, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):33. https://doi.org/10.1167/iovs.66.3.33

Includes: Supplemental Content

Visual Neuroscience March 2025

Perceptual Visual Acuity Declines With Age in a Rat Model of Retinitis Pigmentosa While Light Perception is Maintained

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Naofumi Suematsu; Akinori Y. Sato; Akihiro Kimura; Satoshi Shimegi; Shogo Soma
TAGS: contrast sensitivity, perception, photic stimulation, rats, retinal degeneration, retinitis pigmentosa, vision, visual acuity, neurons, water
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):31. https://doi.org/10.1167/iovs.66.3.31

Includes: Supplemental Content

Cornea March 2025

The Secreted Ly6/uPAR-Related Protein-1 (SLURP1) Protects the Cornea From Oxidative Stress

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Satinder Kaur; Peri Sohnen; Simran Kumar; Mehak Vohra; Sudha Swamynathan; Shivalingappa Swamynathan
TAGS: cornea, oxidative stress, proteins, ultraviolet b radiation, urokinase plasminogen activator receptor, dna damage, mice, lipid peroxidation, oxidation-reduction, ultraviolet rays
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):30. https://doi.org/10.1167/iovs.66.3.30

Includes: Supplemental Content

Retina March 2025

Quantifying the Progression of Stargardt Disease in Double-Null ABCA4 Carriers Using Fundus Autofluorescence Imaging

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Ivana Mihalek; Hanna De Bruyn; Tomislav Glavan; Annie M. Lancos; Caitlin M. Ciolfi; Katarzyna Malendowicz; Sigrid Aslaksen; Laurie L. Molday; Robert S. Molday; Anne B. Fulton
TAGS: abca4 gene, fovea centralis, fundus autofluorescence imaging, pixel, stargardt's disease, artifacts, eye
Trans. Vis. Sci. Tech.. 2025; 14(3):16. https://doi.org/10.1167/tvst.14.3.16

Includes: Supplemental Content

Cornea March 2025

Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro

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Kara Poole; Krithika S. Iyer; David W. Schmidtke; W. Matthew Petroll; Victor D. Varner
TAGS: cornea, fibroblasts, genes, keratocytes, myofibroblasts, transcription, genetic, stromal cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):28. https://doi.org/10.1167/iovs.66.3.28

Includes: Supplemental Content

Glaucoma March 2025

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

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Jing Wang; Yang Zhang; Huimin Zhong; Yumeng Zhang; Ruiqi Han; Yanzhi Guo; Shouyue Huang; Huan Yu; Yisheng Zhong
TAGS: ferroptosis, fibrosis, nadph oxidase 4, silicone oils, smad3 gene, trabecular meshwork, glaucoma, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):25. https://doi.org/10.1167/iovs.66.3.25

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Glaucoma March 2025

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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Jiayong Li; Yuncheng Ma; Lingling Xie; Kaichen Zhuo; Yuxian He; Xin Ma; Shufen Zheng; Shicheng Guo; Yizhen Tang; Guzainuer Muhetaer; Mireayi Aizezi; Dan Zhang; Aizezi Wumaier; Xu Zhang; Chao Tang; Wei Wang; Wenyong Huang; Xinbo Gao
TAGS: biological markers, exfoliation syndrome, mass spectrometry, mendelian randomization analysis, plasma, proteins
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):19. https://doi.org/10.1167/iovs.66.3.19

Includes: Supplemental Content

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Addressing Multiplicity in Retinal Sensitivity Analysis: An Alternative Approach to Assessing Gene Therapy Efficacy in Inherited Retinal Diseases

Topical Administration of Novel FKBP12 Ligand MP-004 Improves Retinal Function and Structure in Retinitis Pigmentosa Models

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

Clinical Value of MLPA for Prognostic Assessment of Chromosomal Rearrangements and DNA Methylation in Uveal Melanoma

Optic Nerve Crush Does Not Induce Retinal Ganglion Cell Loss in the Contralateral Eye

Fibrosis-Related Gene and Protein Expression in Normal and Glaucomatous Trabecular Meshwork Cells

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

Pten Loss Triggers Progressive Photoreceptor Degeneration in an mTORC1-Independent Manner

EFEMP1-Mediated Regulation of Choroidal Vascular Dysfunction in Myopia: Insights Into the FOXO3/VEGFA Pathway as a Therapeutic Target

Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

Perceptual Visual Acuity Declines With Age in a Rat Model of Retinitis Pigmentosa While Light Perception is Maintained

The Secreted Ly6/uPAR-Related Protein-1 (SLURP1) Protects the Cornea From Oxidative Stress

Quantifying the Progression of Stargardt Disease in Double-Null ABCA4 Carriers Using Fundus Autofluorescence Imaging

Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro

Silicone Oil Affects Fibrosis of Human Trabecular Meshwork Cells by Upregulating Ferroptosis Through a ROS/NOX4/Smad3 Axis

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Comprehensive Proteomic Profiling of Exfoliation Glaucoma Via Mass Spectrometry Reveals SVEP1 as a Potential Biomarker

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